ÀÖÓã¹ÙÍø×ÊÖú´ó°ÍÀè°ÙÈ˼ƻ®ÌØÆ¸½ÌÊÚ£¬²©Ê¿Éúµ¼Ê¦¡£½üÄêÀ´Ö÷³Ö¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¹ú¼ÊºÏ×÷Ñо¿ÏîÄ¿¡¢ÃæÉÏÏîÄ¿µÈ¹ú¼Ò¼¶¿ÎÌâ4Ïî£¬ÖØÇìÊÐ×ÔÈ»¿ÆÑ§»ù½ðÃæÉÏÏîÄ¿µÈÊ¡²¿¼¶¿ÎÌâ8Ïî¡£ÒÔµÚÒ»/ͨѶ×÷ÕßÉí·ÝÔÚCell Host & Microbe¡¢PNAS¡¢EMBO Rep¡¢PLoS Pathogens¡¢mBioµÈÆÚ¿¯·¢±íÂÛÎÄ30ÓàÆª£¬±»ÒýÓÃ1200Óà´Î£¬ÊÚȨ¹ú¼Ò·¢Ã÷רÀû2Ïî¡£»ñÖØÇìÓ¢²ÅÇàÄê°Î¼âÈ˲źÍÉÂÎ÷Ê¡ÇàÄêÈ˲ÅÍоټƻ®µÈÊ¡²¿¼¶È˲ÅÏîĿ֧³Ö¡£ºóÐø¹¤×÷½«¼ÌÐøÎ§ÈÆ²¡Ô΢ÉúÎ↑չ£¬Ö¼ÔÚ¸ÐȾÐÔ¼²²¡µÄ·Ö×Ó°ÐÏòÖÎÁƵÈÁìÓòÈ¡µÃÍ»ÆÆ¡£
Ñо¿·½Ïò
Ñо¿·½ÏòÊDz¡Ô΢ÉúÎï¸ÐȾÓëÃâÒߣ¬¹Ø×¢»úÌåÃâÒßϵͳÈçºÎÓ¦¶Ô¸ÐȾºÍ²¡ÔÌåÈçºÎʵÏÖÃâÒßÌӱܵȹؼü¿ÆÑ§ÎÊÌâ¡£Ö÷ÒªÑо¿²¡Ô΢ÉúÎïÓëËÞÖ÷¼äµÄÏ໥×÷Ó㬼ø¶¨Ó벡Ô΢ÉúÎï¸ÐȾÒÔ¼°Ö²¡ÃÜÇÐÏà¹ØµÄ²¡ÔÒò×ÓºÍËÞÖ÷Òò×Ó£¬²ûÃ÷²¡Ô΢ÉúÎï-ËÞÖ÷µ°°×¼äµÄ»¥×÷¼°µ÷¿Ø»úÖÆ¡£¿ÎÌâ×éÓë°ØÁÖ×ÔÓÉ´óѧ£¬¼ÓÖÝ´óѧ²®¿ËÀû·ÖУ£¬¸ùÌØ´óѧ£¬ÖÐɽ´óѧ£¬Î人´óѧ£¬ÖØÇìÒ½¿Æ´óѧµÈ¹úÄÚÍâ¶à¼Ò¿ÆÑе¥Î»½¨Á¢½ôÃܺÏ×÷¹ØÏµ¡£
¿ÎÌâ×é³£ÄêÕÐÊÕ²©Ê¿ºÍ˶ʿÑо¿Éú£¨·Ö×ÓÉúÎïѧ¡¢Ï¸°ûÉúÎïѧ¡¢ÃâÒßѧ·½Ïò£©£¬ÈȳÀ»¶ÓÓÐÔ¶´óÀíÏëºÍÖ¾ÏòµÄͬѧ±¨¿¼£¡
¿ÎÌâ×é³£ÄêÕÐÆ¸¸±½ÌÊÚ£¨Co-PI£©¡¢ºëÉʦ×Ê£©²©Ê¿ºó¼°Ñо¿ÖúÀí£¬´ýÓö´ÓÓÅ£¬ÓÐÒâÕßÇëͶµÝ¼òÀúÖÁÓÊÏähbwu023{at}cqu.edu.cn£¬»¶Ó¸÷λ־ͬµÀºÏÕß¼ÓÃË¿ÎÌâ×飬¹²Ä±·¢Õ¹£¡
Ö÷½²¿Î³Ì
ϸ°ûÉúÎïѧ£¬ÊµÑ鶯Îïѧ
ѧÊõ¼æÖ°
Frontiers in Drug DiscoveryÔÓÖ¾Editor Board-Review Editor£»ÖØÇì΢ÉúÎïѧ»áÀíÊ£»ÖØÇìÊÐϸ°ûÉúÎïѧ»áÀíÊ£»Öйú¿¹°©Ð»áÖ×Áö±êÖ¾Îïרί»áÖ×Áö¶àѧ¿ÆÕï¶Ï£¨MDD£©Ð×÷×éίԱ£»ÖØÇìÊÐÉúÎïÐÅϢѧ»áÖ×ÁöÐÅϢѧרί»áίԱ¡£ÊÜÑûµ£ÈÎNat Commun, Ageing Res Rev, Cell Mol Life Sci, PLoS Genet, Cell Death Dis, JBC, JVIµÈÆÚ¿¯µÄÉó¸åÈË¡£
Ö÷Òª³É¹û
Selected Papers (First or Corresponding author)
1. Wu H, Xing N, Meng K, Fu B, Xue W, Dong P, Tang W, Xiao Y, Liu G, Luo H, Zhu W, Lin X, Meng G, Zhu Z, Nucleocapsid Mutations R203K/G204R Increase the Infectivity, Fitness and Virulence of SARS-CoV-2. Cell Host & Microbe. 2021;29(12):1788-1801.e6
2. Wu H, Wang Y, Zhang Y, Yang M, Lv J, Liu J, and Zhang Y. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. PNAS. 2015, Mar 31; 112(13): E1530¨CE1539. (Featured article, highlighted by Christopher K. Tuggle, PNAS, 2015)
3. Gao Y, Wu H, Wang Y, Liu X, Chen L, Li Q, Cui C, Liu X, Zhang J, Zhang Y. Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biology. 2017,18(1): 13.(Co-first author)
4. Fu B, Lin X, Tan S, Zhang R, Xue W, Zhang H, Zhang S, Zhao Q, Wang Y, Feldman K, Shi L, Zhang S, Nian W, Pavani K, Li Z, Wang X, Wu H. MiR-342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death. EMBO Rep. 2021 Sep 6;22(9):e52252.
5. Fu B, Xue W, Zhang H, Zhang R, Feldman K, Zhao Q, Zhang S, Shi L, Pavani KC, Nian W, Lin X, Wu H. MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling. mBio. 2020, 11:e00557-20.
6. Lin X, Fu B, Yin S, Li Z, Liu H, Zhang H, Xing N, Wang Y, Xue W, Xiong Y, Zhang S, Zhao Q, Xu S, Zhang J, Wang P, Nian W, Wang X, Wu H. ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. iScience. 2021 Apr 23;24(4):102293.
7. Lin X, Fu B, Xiong Y, Xing N, Xue W, Guo D, Zaky M, Pavani K, Kunec D, Trimpert J, Wu H. Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection. PLoS Pathogens. 2023 Jan 23;19(1):e1011128.
»ñ½±Çé¿ö
ÖØÇìÓ¢²ÅÇàÄê°Î¼âÈ˲ţ¬ÉÂÎ÷Ê¡ÇàÄêÈ˲ÅÍоټƻ®
Ñо¿ÉúÅàÑø
Ŀǰ¿ÎÌâ×éÓв©Ê¿ºó3Ãû£¬²©Ê¿Ñо¿Éú4Ãû£¬Ë¶Ê¿Ñо¿Éú6Ãû£¬Óë½¾ü¾üÒ½´óѧµË¹úºê½ÌÊÚµÈÁªºÏÅàÑøÑо¿Éú3Ãû¡£ÒѱÏҵ˶ʿÑо¿Éú3Ãû¡£
ÁªÏµ·½Ê½
Email£ºhbwu023@cqu.edu.cn